2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1351
    Bilberry Extract 84082-34-8 98%
    Bilberry Extract is a bilberry extract, and its components include: Anthocyanidins. Bilberry Extract has potential antioxidant activity and can regulate specific metabolic enzymes in the liver, such as cytochrome P450 (CYP) 2C11 and CYP2E1 involved in drug metabolism..
    Bilberry Extract
  • HY-B2030
    Propanil 709-98-8
    Propanil is a widely used contact herbicide, primarily for rice.
    Propanil
  • HY-B2097
    Incadronate disodium 138330-18-4 98%
    Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (Ki=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC50=64 μM). Incadronate disodium has the potential for malignant tumors research.
    Incadronate disodium
  • HY-D2261
    BODIPY-cholesterol conjugate-1 1638745-25-1 98%
    BODIPY-cholesterol conjugate-1 (compound 5) is a BODIPY-cholesterol conjugate. BODIPY-cholesterol conjugate-1 is a useful probe for simultaneous visualization of intracellular cholesterol pools and for monitoring cholesterol efflux from cells to extracellular acceptors. (λex 541 nm, λem 615 nm).
    BODIPY-cholesterol conjugate-1
  • HY-D2262
    BODIPY-cholesterol conjugate-2 1638745-26-2 98%
    BODIPY-cholesterol conjugate-2 (compound 6) is a BODIPY-cholesterol conjugate. BODIPY-cholesterol conjugate-2 is a useful probe for simultaneous visualization of intracellular cholesterol pools and for monitoring cholesterol efflux from cells to extracellular acceptors. (λex=589 nm, λem=638 nm).
    BODIPY-cholesterol conjugate-2
  • HY-D2357
    Lactat-CY5 98%
    Lactat-CY5 is Cy5-labeled Lactat (HY-B2227). Lactat-CY5 can be used to localize Lactat in living cells.
    Lactat-CY5
  • HY-D2358
    Glucosamine-CY5.5 98%
    Glucosamine-CY5.5 is CY5.5-labeled Glucosamine (HY-B1125). Glucosamine-CY5.5 can be used to localize Glucosamine in living cells.
    Glucosamine-CY5.5
  • HY-D2359
    Glucosamine-FITC 98%
    Glucosamine-FITC is FITC-labeled Glucosamine (HY-B1125). Glucosamine-FITC can be used to localize Glucosamine in living cells.
    Glucosamine-FITC
  • HY-D2414
    SCOTfluor-89 2490298-72-9 98%
    SCOTfluor-89 is a small, conjugatable, orthogonal and multi-colored fluorophores for in vivo imaging of cell metabolism.
    SCOTfluor-89
  • HY-D2480
    BODIPY 480/508-cholesteryl linoleate 2260795-60-4 98%
    BODIPY 480/508-cholesteryl linoleate is a cell-permeable and fluorescently tagged derivative of Cholesteryl Linoleate (HY-W010697). BODIPY 480/508-cholesteryl linoleate has been used to monitor cholesterol trafficking in isolated human monocyte-derived macrophages (Ex/Em=480/508 nm).
    BODIPY 480/508-cholesteryl linoleate
  • HY-G0010
    Netupitant metabolite N-desmethyl Netupitant 290296-72-9 98%
    N-desmethyl Netupitant is a metabolite of Netupitant, which is an antiemitic drug.
    Netupitant metabolite N-desmethyl Netupitant
  • HY-N0716
    Berberine 2086-83-1 98%
    Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability.
    Berberine
  • HY-N1867
    trans-Cinnamyl alcohol 4407-36-7 ≥98.0%
    trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite.
    trans-Cinnamyl alcohol
  • HY-N2018
    α-D-Xylose 6763-34-4
    α-D-Xylose (α-D-Xylopyranose) is a basic component of the five-carbon fraction of biomass and a precursor of hemicellulose. α-D-Xylose participates in a variety of enzyme-catalyzed reactions, which in turn participate in a variety of metabolic pathways. In addition, α-D-Xylose is also used in tanning, dyeing and as a diabetic food.
    α-D-Xylose
  • HY-N2087
    Ligupurpuroside A 147396-01-8 98%
    Ligupurpuroside A is an active product that can be extracted from Ligustrum robustum. Ligupurpuroside A acts as a natural inhibitor of lipase in a competitive manner.
    Ligupurpuroside A
  • HY-N2351
    Paeonoside 20309-70-0 98%
    Paeonoside is a bioactive compound identified in P. suffruticosa that promotes wound healing and migration in osteoblast differentiation. Paeonoside has also been reported to have some antidiabetic activity and may prevent sepsis-induced lethality.
    Paeonoside
  • HY-N2720
    6-O-Caffeoylarbutin 136172-60-6 98%
    6-O-Caffeoylarbutin (Robustaside B) possesses antioxidant activity.
    6-O-Caffeoylarbutin
  • HY-N2953
    Borapetoside E 151200-49-6 98%
    Borapetoside E can be isolated from T. crispa. Borapetoside E improves hyperglycemia, insulin resistance, hepatic steatosis, hyperlipidemia, and oxygen consumption in obese mice. Borapetoside E also inhibits SREBPs expression in the liver and adipose tissue.
    Borapetoside E
  • HY-N3185
    N-Methylcalycinine 86537-66-8 98%
    N-Methylcalycinine is a nature product with AChE inhibitory activity. N-Methylcalycinine can be isolated from the roots of Stephania epigaea. N-Methylcalycinine can be used for the research of asthma, cancer, dysentery, fever, hyperglycemia, intestinal complaints, inflammation, sleep disturbances, tuberculosis and so on.
    N-Methylcalycinine
  • HY-N3391
    Leuconolam 93710-27-1 98%
    Leuconolam is an alkaloid that undergoes various chemical transformations, including base-induced cyclization to produce diisomeric products.
    Leuconolam
Cat. No. Product Name / Synonyms Application Reactivity